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Posts Tagged ‘medicine’

Low-tech Antiseptics, part 1

These posts brought to you by the recurrence of the search term “boiling wine” bringing people to my little rant on the use of same on wounds in GRRM’s A Song of Ice and Fire series.

Magical healing aside, basic sanitation is the one thing that will most increase your characters’ chances of survival when they’re injured. Stitches are helpful. So are herbs. Splints are important for broken bones. But if that cut gets infected, abscesses, and gangrene sets in, all the willow bark tea in the world isn’t going to save you.

In real-world history, the importance of keeping wounds clean was not fully realized until only a few hundred years ago. Why your fantasy world’s physicians know they need to do this is up to you. I’m going to look at how to do it in a world without industrialized chemical analysis and synthesis.

Salt

Gargling saltwater for a sore throat and old recipes for toothpaste made of salt and baking soda (more on that later) work because salt does kill microbes when it’s concentrated enough. This is why pickling and salting work as food preservatives.

Pickled characters

Brine recipes call for anywhere from a half cup to a cup of salt per gallon of water, which would be 3 – 6% salt by volume. Seawater tends to be more like 3 – 4%.

Depending on where your characters are, seawater could be easy to get and a reasonable thing to wash a wound with — if the seawater has been filtered and hopefully boiled as well. It does contain microbes that are acclimated to salty water, after all.

Brine prepared from salt and boiled water is a viable option if your characters have access to economically priced salt. Or maybe it’s a rare and expensive way to treat wounds, reserved only for those who can afford it. Either way, I recommend Mark Kurlansky’s Salt as an excellent overview of salt production over the course of history.

Character jerky

Given a supply of fairly pure salt, why not just pack the wound with salt? Yes, that’s been done in the past. Especially with abscesses, it seems. The packing needs to be changed a few times a day, and after the salt’s done its job the wound will need to be closed by whatever method and given a chance to heal. You don’t actually want to make jerky out of your character.

Sodium bicarbonate

You know it better as baking soda. Combined with salt and a little water, baking soda makes for a nasty-tasting toothpaste but it’ll kill those germs and even bleach your teeth a little.

Naturally occurring bicarbonate is one of several compounds found in natron, which the Egyptians used for cleaning, an antiseptic, and to preserve mummies. Natron is mined from natural deposits, which can be found in a variety of places — not just deserts. Perhaps this would be a viable industry for your fantasy kingdom on top of its medical uses.

Baking soda mouthwash recipes range up to 25% concentration but tend to fall more around a teaspoon per half pint of water which would be… 4%? As with salt above, your healers could use either a brine to wash wounds or pack the wound directly with natron — bearing in mind that we don’t want to mummify the characters just yet. Natron is a drying agent, which means it draws out moisture from the tissues. This makes the tissues less hospitable to bacteria… and life in general.

Stay tuned for the more accurate use of alcohol (not by boiling wine, for crying out loud) and an antiseptic wild card.

Empty your memory trash can? (This action cannot be undone)

PKMzeta is shaping up to be a single, target-able protein in the brain responsible for reconsolidating memories. Discover ran a three part article on it and there was a recent article in Wired, too — the original scientific papers are behind subscription walls, unfortunately.

In brief, reconsolidation is a maintenance process for long-term memories. We think our memories are firm and unchanging, but plenty of studies have proven that they aren’t. They shift a little each time we remember them, each time we reconsolidate them, and over time those shifts add up. (And they’re often inaccurate to begin with, but that’s another issue.)

PKMzeta is a protien that hangs out in the synapses between neurons and maintains a particular ion channel so that the neuron is able to receive signals from the neighbors. Without PKMzeta, the number of those particular ion channels drops and the neuron becomes less sensitive to nearby activity.

Block the PKMzeta when a memory is undergoing reconsolidation and the memory will fade.We already have one drug (propranolol) that does this, and there are sure to be more.

There are tons of questions still to be answered, of course. And there are tons of possible uses and abuses of such a thing. This is such a gold mine of science fiction possibilities that I’m sure I don’t have to list them. But I would like to bring up one.

“This isn’t Eternal Sunshine of a Spotless Mind-style mindwiping” the article in Wired says. That may be true, but it also does not address an excellent question that movie poses (if you haven’t seen it, I recommend it.) The question being: you can remove the memories associated with a bad relationship with a person, but what about the underlying attraction that drew you to that person in the first place? One of the implications I got from that movie was that the two of them were stuck in a cycle of attraction, falling apart and voluntary mind-wipes.

For “person,” above, substitute anything you like. Kittens. Drugs. Street racing. World domination… like I said, a gold mine of possibilities here.

Science Hacks Our Fiction (And The Feeling Is Mutual)

Science fiction loves robots to pieces, but fortunately for genre writers and fans, the feeling is mutual. Engineers and scientists are working near-miracles in the robotics field, and the fruits of their labor are ripe for fiction’s picking. 2012 is still young by most accounts, yet this year robots have already grown tails and scales, acquired aerial speed limits, and learned to swim like a boss. Next they’ll be popping-up in swarms and colonizing our eaves. Or better yet: We’ll wear them on our hands to reduce the repetitive stress injuries we’re causing ourselves by trying to write ever-cleverer new robots into science fiction faster than actual science can render the bots of our dreams obsolete.

Probably the only way we writers can keep up with – or even hope to outpace – the current rate of robotic development is by imagining new purposes and roles for robots. It’s unlikely that scientists and engineers will ever stop endeavoring to simulate humanity and integrate androids into society, as lofty as that goal is. But if real bots must eventually look like and learn like humans, the least we can do is give readers more interesting robots to read about than the one that sweeps floors and amuses cats, or the android in the kitchen with Dinah. We already use droids for offense and defense, manufacturing, and surgery. Robotic search and rescue is a high priority for research and development, and it looks like construction may soon be crawling with bots. So what frontiers does that leave fiction to explore?

Plenty. The world already includes many different kinds of robots with different functions and forms, and the diversity of artificial ‘species’ will only continue to expand (even as natural diversity contracts at an alarming rate). As robots abound, they will inevitably need to interact well with natural species and with each other in order to satisfy human demands. They’ll need to function optimally with a minimum of human guidance, and endure at times in spite of human intervention. Face it: We abuse our tools and hack our toys. Robots need to be resilient just to survive life among humans. There’s enough fodder for stories in those last few sentences alone to keep an author busy for the length of a so-called Golden Age of fiction…

The strange android had stepped from behind an overgrown bougainvillea and disabled their Guardians before they’d even known it was there. “Remain calm, children. I won’t hurt you.” It spoke like a classic film actress, its voice a disarming combination of cultured and flinty that the boys recognized from their seventh grade film history elective but had never heard in person. Read an excerpt from ‘Parent Hack’ by Kay T. Holt

Illness and Medicine: A Google+ worldbuilding hangout report

Note: This article is a report on a live discussion I had with Janet Harriet, Harry Markov, and Glenda Pfeiffer on Google+. Our topic was Illness and medicine.

One of the fundamental underpinnings of any culture of illness and medicine is the idea of cause and effect. The way that we treat people, and the types of medicine we pursue, are based on our understanding of the causes of illness. Thus, when a people believes that illness is caused by evil spirits, the medical approach will typically address this problem directly by providing exorcisms and other spiritual approaches. When a people possesses the idea of germ theory, that fundamentally changes the approach to one of finding medicines to deal with the germs in question. There is also the possibility that medicine may be an empirical/experimental practice, which is to say that a people may have found out through fortuitous circumstance that eating a certain plant will cure headaches, or stop a certain kind of illness. In this case the cause of illness may not be considered particularly relevant. Janet felt that (at least historically) midwives have had an expertise that grows out of this kind of learn-by-experience approach. And Harry mentioned that if you have a magical healing system, the sense of cause might not even be necessary.

On the other hand, a logic of magical healing is necessary. This logic can grow out of the general logic of a magic system, or out of some kind of medically based model, but it needs to feel grounded. I mentioned how I’d worked with Janice Hardy when she was setting up some of the cultural underpinnings of the magical healing system she used in The Healing Wars. In this system, healers are able magically to perceive injury and hurt, and to heal it, but must take the pain of it into their own bodies. Then they have to push the pain out into a magical metal which stores it (and is in short supply). This metal is in turn forged into pain-shooting weapons, creating a pain-based economy. Believe me, this is a fascinating trilogy – but at the start we were looking for answers to questions like these:

Who are physicians?
Why are they chosen as doctors?
What is the role of doctors in the culture?
What are the limitations on doctors?
Is there any alternative to the magical healing system?

In fact, people who use plants and other substances to heal are considered dirty in Janice’s world, and dangerously unreliable…but the system would have seemed incomplete without them.

I believe it was Harry who mentioned that in the Anime series “Bleach” there is a character who can do what looks like healing, but is actually a localized reversal of time that reverts the damage to its previous condition. Harry shared a logistical issue he’s been dealing with in his work in progress, where magic can be used to heal, but at the same time, using magic is a drain on life force. So what happens if you try to heal yourself? It could be complex…

Glenda asked, “How do the magical healers conceptualize healing and illness?” This is an excellent question. Very often we use metaphors to describe illness; this can influence our treatment of it in addition to our general concept of its cause. Magical healers who are aware of physiology will treat people very differently from those who are not. Harry’s system has complex rituals – like recipes – for tissue repair. Thus the healer need not know too much about physiology, only how to follow the rituals, and of course he/she must have the magic ability to activate the process.

It is worth doing research when you’re dealing with illness and medicine in your writing. Don’t just gesture at what is possible. I’ve gone and looked up how to treat bruises, and I’ve looked up the different types of recognized mental illnesses, and a lot of other things as well. It’s also worth considering the scope of what doctors are called on to treat. As Harry noted, homosexuality has sometimes been considered a mental condition that requires “treatment.”

What can you alter in your world? There are lots of underlying parameters that are open to change. For example, who is more important, the doctor or the patient? Who has the power, and why? Can you ask questions about the recommended treatments, such as why and how they are to be delivered? Can you refuse treatment?

It’s important to keep in mind also that doctors are knowledge elites, much like priests. They undergo special training, and have knowledge that must be protected and treated with respect. Often they can engage the services of gatekeepers to help them accomplish this. In the case of a system based on evil spirit possession, the roles of doctor and priest can overlap. Even today, Harry told us, people worry about the “evil eye” in Bulgaria: if people look at you and think you’re pretty they will jinx you and make you feel ill; grandmothers will recommend washing your eyes three times at the door and washing the door handle and then you should be fine. Exorcisms still happen, and mental illness can sometimes be labeled as possession.

The metaphors we use to describe our bodies and our health are very resistant to change over time, and they can deeply affect our behavior. If you’re worldbuilding, this is a wonderful area to spend time developing because tiny phrases will speak volumes about the way your people think. Here are some expressions that the discussion participants shared:

“The hamster that runs my brain fell off.”
“One of your boards is loose.”
“Losing your marbles”
“Not playing with a full deck”
“You’ve let go like liver” (in Bulgaria describes lounging around lazily)
“A seagull has eaten your brain”

I wrote a post some time ago called Body Models and Metaphors, which was about how one decides when to seek medical treatment. Some people base their decision on the amount of time one has been sick, while others base their decision on specific types of changes in the health condition.

Some final things we mentioned were terminal illness and palliative care, medical insurance, and issues of public health and vaccination.

In Japan, very often the person who has a terminal illness will not be told, because it is believed that the knowledge would trouble them unnecessarily. Instead, the family will be told, and the patient simply expected to follow doctor’s orders without any knowledge of the reason. I linked to the article called “How Doctors Die” which is also relevant here, about the cultural conditions that lead us to expend so much money on torturous last-ditch treatments when people are near death. The question of medical insurance comes along with the role of government in public health in the society you’re designing. Does this society have a concept of spreading the risk across the population? How might a government respond to issues of public health when it is responsible for safeguarding public health and sponsoring treatment? In Australia, the government puts out pretty stiff advertising against unhealthful behavior that brings significant expense upon the public health system. One would expect vaccinations to be heavily supported in an environment like that, whereas in the US a lot of people have been convinced by fraudulent argumentation that vaccinations cause autism or other disorders… leading directly to public health problems such as the resurgence of diseases like measles and whooping cough. There can also be questions of whether one group in society is disproportionately affected by one health condition or another – such as Tay-Sachs disease affecting Jewish people, or royal families having a tendency to carry hemophilia. In my Varin world the noble caste is heavily inbred and so everybody has some kind of health difficulties (or if they don’t have them currently, they still might have had difficulties at birth).

Obviously there’s far more than can be covered in one hour, but I hope these thoughts have given you some inspiration.

Traumatic Brain Injury

Last spring, I put out a call on my public journal for topic suggestions. A friend of mine and traumatic brain injury [Wikipedia] (TBI) survivor suggested I explore what TBI [Mayo Clinic] has taught us.

Like many of the topics I’ve written about here, I had much to learn before I could begin. Once I researched TBI [Neurologic Rehabilitation Institute at Brookhaven Hospital], I had difficulty breaking the vast topic [Open Directory] back down into a streamlined piece. I have my former editor, Kay Holt, to thank for some of the links I will be including and also for the flow of the piece. As usual, the links will take you to articles that explore the main and related topics more thoroughly. Please have a look beneath the surface.

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Extending Medical Nanotech

A couple weeks ago, Calvin Johnson wrote an interesting post on nanotechnology, discussing some of the proposals, current research, and ways to write about it in a more realistic manner. One application he didn’t touch on, however, was the current work being done in nanomedicine.

Most current medical nanotech takes the form of either microscopic drug vectors tuned to open for certain wavelengths of light, or particles designed to identify cancers by infiltrating cells or locking onto certain proteins. These particles are largely organic and often designed to mimic the actions of antibodies. All these methods are being touted as ways to combat not only cancer and infections, but have also been used to repair tissue damage following heart transplants.
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