Empty your memory trash can? (This action cannot be undone)

PKMzeta is shaping up to be a single, target-able protein in the brain responsible for reconsolidating memories. Discover ran a three part article on it and there was a recent article in Wired, too — the original scientific papers are behind subscription walls, unfortunately.

In brief, reconsolidation is a maintenance process for long-term memories. We think our memories are firm and unchanging, but plenty of studies have proven that they aren’t. They shift a little each time we remember them, each time we reconsolidate them, and over time those shifts add up. (And they’re often inaccurate to begin with, but that’s another issue.)

PKMzeta is a protien that hangs out in the synapses between neurons and maintains a particular ion channel so that the neuron is able to receive signals from the neighbors. Without PKMzeta, the number of those particular ion channels drops and the neuron becomes less sensitive to nearby activity.

Block the PKMzeta when a memory is undergoing reconsolidation and the memory will fade.We already have one drug (propranolol) that does this, and there are sure to be more.

There are tons of questions still to be answered, of course. And there are tons of possible uses and abuses of such a thing. This is such a gold mine of science fiction possibilities that I’m sure I don’t have to list them. But I would like to bring up one.

“This isn’t Eternal Sunshine of a Spotless Mind-style mindwiping” the article in Wired says. That may be true, but it also does not address an excellent question that movie poses (if you haven’t seen it, I recommend it.) The question being: you can remove the memories associated with a bad relationship with a person, but what about the underlying attraction that drew you to that person in the first place? One of the implications I got from that movie was that the two of them were stuck in a cycle of attraction, falling apart and voluntary mind-wipes.

For “person,” above, substitute anything you like. Kittens. Drugs. Street racing. World domination… like I said, a gold mine of possibilities here.

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